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L-erthioneine You have been proposed as a potential longevity vitamin, highlighting its role as a Powerful antioxidant That Operates Within Cells to Counteract Oxidative Stress (1).
Although Primarily Synthesized in Mushrooms, Fungi, and Soil Bacteria, Ergothioneine Is Found in Almost All Human Cells Due To The Presence of A Highly Spatific Transporter. Being out externally sourced, its widespretad distribution in the body suggests its importance in promoting Human Health. Studies Have Shown That Ergothioneine Can Preserve Telomere Length and Slow Down Telomere Shortunteing Under Conditions of Oxidative Stress, Indicating the Potential Benefits of Ergothioneine for Healthy Ageing (2). Furthermore, Emerging Research Suggests Possible Advantages for Cognitive Function, Immune System Support, Prostate Health, and Cardiovascular Well-Being.
Over The Past Decade, Ergothioneine, Naturally Occurring Sulfur-Modified Amino Acid, you have attracted a lot of interest to potential Therapeutic Compound. According to published scientific evidence, Ergothioneine Postseses A Strong Antioxidant and Anti-Inflammatory Tranacity.
You are virtues lead The Scientific Community to Study ITS Action on Cardiovascular Diseases, Chronic Inflammatory Desases, Damage Neuronal, Cellular Ageing and Even Cancer. It is said to be so important that I will be considered vitamin!
Moreover, Ergothioneine is not synthesized by Humans, Even Though it is widely present in the tissues of plants and animals. It Turns out that Mushrooms Are The Ricest Food Source.
In This article, We Take Stock of the Potential of this Molecule On Our Health.
What is ergothioneine?
L-erthioneine, an amino acid buying histidine and a sulfur atom, was first identified by French Pharmacist Charles Tanret in Rye Ergot (Claviceps Purpurea) in 1909. PRIMARILY COLLECT FOR ITS ANTIOXIDATIVE AND CYTOPROTECTIVE PROPERTIES AGAINST OXIDE STRESS, ERGOTHIONEINE ALSO ANTI-INFLAMMATORY AND Detoxifying Effects.
GIVEN than ONLY select microorganisms possess the capability to synthesise ergothioneine, it is acquired ThisTary Sources. UPON INGESTION, Ergothioneine is absorbed in the gastrointestinal tract and distributed to Various Organs, Boasting Good Bioavailability.
Ergothioneine Demonstrates at the propensity to Accumulate in Nearly All Cells and Tissues, With Height You have concentrated in Those subjected to oxidative stress and injury. Individually Found in Erythrocytes, Spleen, Liver, and Ocular Tissues, ITS LEVELS DIMINISH WITH ADVANCING AGE, particularly Beyond 60 Years of Age.
WHERE IS ERGothioneine Found?
As observed, Ergothione is primarily obtained from Mushrooms Ergothioneine Can Also Be Found in Other Foods Such As Shellfish and Meat, Although in Lower Quantities ..
Studies Show That It is the fruits (Aerial Parts) of Basidiomycetous Mushrooms Such As Chaga, Boletus edulis (CEP, Porcini and Penny Bun), Oyster Mushrooms, Lions Mane, Shiitake Mushrooms, and Even Cordyceps Mushrooms, notable for their abundant levels of ergothioneine. Consumption Supplements Containing Ergothioneine is a great way to incorporate this Valuable Nutrient Indo your diet.
Ergothionine is not the only antioxidant compound Found Mushrooms since the extracts also contain ergosterol, Ascorbic Acid, flavonoids, tocopherols, carotenoids, Beta-Glucans and Even Phenolic Compounds.
Ergothioneine: A smart antioxidant?
It has been establishing that Ergothioneine Serves As a Protective Agent for Cells, Combating Oxidative Stress and Inflammation. Alongsis Tohese Compsing Properties, The Mechanisms by Which Ergothioneine Estrars Our Cells Are Equally Intruguing. ITS Cellular Uptake Appears to Be Government by The Expression of A Specialised Transporter, Induced by Oxidive Stress, Suggesting That Ergothioneine INTERVENES REQUIRELY WHEN CELLS REQUIRE ITS ASSISTANCE.
FURTERMORE, ESSUMPTIONS INITIAL ESCITE, A 2017 STUDY REVALED THAT SUPPLICATION WITH ERGOTHIONEINE IN HEALTHY, YOUNG INDIVIDUALS WAS ASSOCIATED WITH A MODEST DECREASE IN OXIDATIVE STRESS MARKER LEVELS.
Ergothioneine: A Fountain of Youth
Promoting Healthy Ageing is Essential for Enhancing The Quality of Life. The Rise in Oxidative Stress As We Age is a Key Factor Linked To Age-Relaged Diseases, particularly neurodegenerative disorders. Consumption an antioxidant-rich diet has been demonstrated to have substantial impact on the ageing process. Strategically Targeting Mechanisms of Ageing Could Be A Valuable Strategy for Enhancing Overall Health.
The Concentration of Ergothioneine in the Bloodstream Declines with Advancing Age, and Is Linked to the Emergency of Diverse Diseases (3). Ergothioneine (EGT), A Water-Soluble Molecule Facitated by A SPECIFFORTER TERMED OCTN1, PROMISING INDICATIONS INDESARCH FOR ITS POTENTIAL ANTI-GENING ATTRUBES POTENTIAL.
Ergothionine & The Cardiovascular System
In the cardiovascular Field, Ergothioneine Sems to Be Promising. Among The Available Studies, We Note That Ergothioneine Supplementation is Associated With Beneficial Effects in Vitro and Animals Models Presenting Manifestations of Cardiometabolic Diseases Such As Type 2 Diabetes, Cardiovascular Designations, Metabolic Syndrome and Nafld.
When looking at humans, retrospective studies have identified associations Between Ergothioneine consumption, Blood Levels, and Improveda Markers of Oxidative Stress and Inflammation, as Well As Lower Risk of Disease. Cardiometabolic and Mortality.
References- AMES BN. Prolonging Healthy Ageing: Longevity Vitamins and Proteins. PNAS, 2018; 115 (43): 10836-10844.
- Samuel P, et al. Ergothioneine Mitigates Telomere Shortening Under Oxidative Stress Conditions. J of Dietary Supplements. 2020; DOI: 10.1080/19390211.2020.185491
- Cheeah, Irwin K., and Barry Halliwell. "Ergothioneine, Recent Developments." Redox Biology 42 (2021): 101868.